N,n,dimethylformamide is produced, as an intermediate or a final product, by process units covered under this subpart. Msds 0464 dimethyl formamide product codes revision date 04may2011 eu endocrine disrupters candidate list eu endocrine disruptors evaluated substances japan endocrine disruptor. Listed as a hazardous air pollutant hap generally known or suspected to cause serious health problems. This sequencinggrade dimethylformamide is specially purified by a proprietary method and tested to ensure lottol. Material safety data sheet i301 perovskite ink dmf, dmso. N,ndimethylformamide dmf is a volatile solvent, albeit with a low evaporation rate. Kleiner, in macsweens pathology of the liver seventh edition, 2018. Uses advised against food, drug, pesticide or biocidal product use. P271 use only outdoors or in a wellventilated area. Hazards identification target organs skin, eyes, respiratory system, central nervous system cns, blood, liver, kidney, spleen potential health effects acute effects principle routes of exposure. N,n dimethylformamide dmf was a chemical proposed for committee consideration at their november 19, 2007 meeting.
Application n,n dimethylformamide was used to solubilize mtt crystals in cell viability assays. Read the product manufacturers material safety data. It is widely employed reagent in organic synthesis. Dimethylformamide solvent for peptide coupling, used as a wash after each deprotection and coupling step in tboc, used as a solvent in fmoc, solvent with low evaporation rate, catalyst in synthesis of acid halides. Please note that certain data fields will be generic and may or may not reflect the information relevant to the recipient andor the materialpackage size including but not limited to the manufacturersupplier address. Dimethylformamide other means of identification product no 92, 5362, 9344, 4929, 9222, 9221, 9220 recommended use and restriction on use recommended use. N,n dimethylformamide 68122 hazard summary dimethylformamide is used as an industrial solvent and in the production of fibers, films, and surface coatings. N,ndimethylformamide product number d 4551 store at room temperature product description molecular formula.
D1, d11, d14 synonyms dmf recommended use laboratory chemicals 2. P280 wear eye protection, face protection, protective clothing, protective gloves. To the best of our knowledge, the chemical, physical. N,ndimethylformamide cas 68122 822275 emd millipore. The resulting fully cured polyurethane resin is a solid film or skin that is considered harmless. It is used in the chemical industry as a solvent, a chemical intermediate, and an additive.
Material safety data sheet section 1 chemical product and company identification msds name. No specific test data related to reactivity available for this product or its ingredients. N,ndimethylformamide d4551 product information sheet. Msds 0464 dimethyl formamide product codes revision date 04may2011 eu endocrine disrupters candidate list eu endocrine disruptors evaluated substances japan endocrine disruptor information target organ effects liver, kidneys, heart, blood, respiratory system, reproductive system. Commonly abbreviated as dmf although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate, this. N,n dimethylformamide is a derivative of formamide, whereby the amino hydrogens are replaced by methyl groups. Further experience with the rangefinding test in the industrial toxicology laboratory. Material safety data sheet n,ndimethylformamide msds section 1.
Chemical product and company identification product name. It can harm the eyes, skin, lungs, liver, and heart. List of all languages of msds for eastmantm 2ethylhexanol. The solvent properties of dmf are particularly attractive because of the high dielectric constant, the aprotic nature of the solvent, its wide liquid range and low volatility. Material safety data sheet n,n dimethylformamide msds section 1. Commonly abbreviated as dmf although this initialism is sometimes used for dimethylfuran, or dimethyl fumarate, this colourless liquid is miscible with water and the majority of organic liquids. Product name n,n dimethylformamide d7 casno 4472417 synonyms no information available recommended use laboratory chemicals. Safety data sheet according to 29cfr19101200 and ghs rev. Dmf or dmfa dmf is an organic solvent produced in large quantities throughout the world. It plays multiple roles in various reactions such as solvent, dehydrating agent, reducing agent as well as catalyst. The solvent properties of dmf are particularly attractive because of the high dielectric constant, the aprotic nature. Page 3 of 5 7 handling and storage precautions for safe handling.
Product and company identification recommended use reagent contact manufacturer kpl, inc. N,ndimethylformamide 68122 hazard summary dimethylformamide is used as an industrial solvent and in the production of fibers, films, and surface coatings. Further experience with the rangefinding test in the. Safety data sheet according to federal register vol.
Thermo scientific pierce dimethylformamide dmf is a sequencinggrade preparation with high purity and consistent absorptivity properties for use in hplc and mass spectrometry methods. Details of the supplier of the safety data sheet emergency telephone number for information us call. Acetone safety data sheet according to federal register vol. It has a role as a polar aprotic solvent and a hepatotoxic agent. The september 7 th notice also marked the start of a 60day comment period during which interested parties could submit comments to oehha that would be forwarded to the members of the cic prior to the november 2007 meeting. No warranty, express or implied, is made and labchem inc. Dimethylformamide is an organic compound with the formula ch 3 2 ncoh. N,ndimethylformamide is considered to be a potent liver toxin. Eye contact contact with dimethylformamide may cause moderate to severe irritation, tearing, pain, corneal opacity, or temporary corneal injury. Acute shortterm exposure to dimethylformamide has been observed to damage the liver in animals and in humans. Draft background document for n,n dimethylformamide dmf.
N, n dimethylformamide dmf is a solvent with a low evaporation rate, useful for preparing solutions with a variety of hydrophobic organic compounds used in molecular biology applications. N, ndimethylformamide dmf is a solvent with a low evaporation rate, useful for preparing solutions with a variety of hydrophobic organic compounds used in. Hconch32 material safety data sheet n,ndimethylformamide msds. Chemical information document for dimethylformamide dmf. Dmf is a useful solvent employed for the isolation of chlorophyll from plant tissues. Identification product name n,n dimethylformamide d7 casno 4472417 synonyms no information available recommended use laboratory chemicals. Product name n,ndimethylformamide for analysis emsure acs,iso,reag. Dmf is a high production volume chemical, primarily used as an industrial solvent u. About 48% of these are pharmaceutical intermediates, 27% are dyestuff intermediates, and 53% are syntheses material intermediates. It is frequently used for chemical reactions and other applications, which. Dimethylformamide an overview sciencedirect topics. N, ndimethylformamide dmf is a clear liquid that has been widely used in industries as a solvent, an additive, or an intermediate because of its extensive miscibility with water and most common organic. Dimethylformamide dmf is a widely used solvent used in the synthetic resin and leather.
N,n dimethylformamide is considered to be a potent liver toxin. Material safety data sheet n,ndimethylformamide msds. Companies may have immediate legal obligations following the inclusion of a substance in. Product and company identification product name n,ndimethylformamide cat no. Identification product name n,ndimethylformamided7 casno 4472417 synonyms no information. Section 1 n,ndimethylformamide 1 chemical product and company identification msds name.
Product codesmsds 0464 dimethyl formamide revision. Dimethylformamide dmf is a widely used solvent used in the synthetic resin and leather industries that causes doserelated massive necrosis in animals 3 and is capable of producing focal hepatic necrosis and microvesicular steatosis in humans, the severity of which correlates with the duration of occupational exposure. None information in this msds is from available published sources and is believed to be accurate. It is a volatile organic compound and a member of formamides. Chemtrec 8004249300 outside usa 7035273887 1216 6th ave n kent wa 98032 phone. Msds contains all the information required by the cpr. Product codesmsds 0464 dimethyl formamide revision date. N,n dimethylformamide is a member of the class of formamides that is formamide in which the amino hydrogens are replaced by methyl groups. In case of contact, immediately flush eyes with plenty of water for a t least 15 minutes. Ph eur the safety data sheets for catalogue items are available at.
Intrinsic properties n,n dimethylformamide dmf was identified as a substance of very high concern svhc according to article 57 c as it is classified in annex vi, part 3. N,ndimethylformamide msds material safety data sheet or sds, coa and coq, dossiers, brochures and other available documents. The user must determine suitability of this information for his application. Symptoms of acute exposure in humans include abdominal pain, nausea. View or download the n,ndimethylformamide msds material safety data sheet or sds for 103034 from merck. Only the candidate list published on this website is deemed authentic. Msds dimethylformamide page 1 of 9 material safety data sheet. Workers may be harmed from exposure to dimethylformamide. Sds of n,ndimethylformamide, safety data sheets, cas 68122. To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Safety data sheet northwest missouri state university. Sds of n,ndiethylformamide, safety data sheets, cas 617845. Safety data sheet creation date 12jan2015 revision date 19jan2018 revision number 4 1. Please note that certain data fields will be generic and may or may not reflect the information relevant to the recipient andor the.
Toxicity data skin rabbit 4,720 mgkg ld50 oral rat 2,800 mgkg ld50 6 hr. Dmf, dmfa1 this product is designated as molecular biology grade. N,n dimethylformamide dmf is the commonly employed solvent for chemical reactions. Dimethylformamide dmf is a clear, colorless, hygroscopic liquid with a slight amine odor.
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